The first wormhole ever encountered by humans were by the SS Louisiana, a exploratory vessel sent out by the UESPA, the ship was caught in by a gravimetric eddy and lost, the crew marooned and discovered 4 centuries later by the USS Inventum.
Beginning nearly a century later and onward, wormholes were discovered, given a order of probability of 1 out of every 13 or 19 missions of a warp-capable vessel. Being mildly uncommon, although neutrino particle densities, particle flux ratios, and/or irregularities could be isolated and studied to indicate potential wormholes.
In 2407, a Particle Physicist theorized that the neutrino particle densities were higher than normal around wormholes were because of medium-intensity share of neutrinos between the 2 apertures of the wormhole in subspace. It was raised to a hypothetical level when impurities of neutrinos on the exact spot of the event horizon of the Bajoran wormhole were discovered.
Primarily, wormholes were utilized as a means of distant transportation. Centurian propulsion was based off of complex form of a singularity-engine created a quantum singularity which then was manipulated to temporarily fold space-time allowing for a turbulent, but efficient transport.
In 3143, the Typhon Wormhole was discovered to lead to the Andromenda Galaxy, although galactic radiation was so severe there that 10 seconds from exiting the second aperture of the wormhole, radiation levels went to over 300 isorems.