Vanguard may refer to:
- Vanguard-class, a type of star cruiser subclass of the Emissary-class.
- USS Vanguard (NCC-2709), a Constitution-class heavy cruiser from the alternate reality
- USS Vanguard (NCC-71828), a Galaxy-class explorer in service in the 24th century
- USS Vanguard (NCC-94996), prototype of the Vanguard-class star cruisers, in service in the late 24th and early 25th centuries.