Tzopharn is an entity that comes from the first dimension. It has a synchronomonal stance that can cause entropy to occur on nearby starships. The USS Yindi was the first to encounter and document the encounter. The Tzopharn can take on psychological decay for multiple species(as also resulting hybrids); a few known species are the humans, the Klingons and chandir. Medical services have been shown to be useful for individuals after encounters.

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