Starfleet Commander-in-Chief, also known as C-in-C, Commander Starfleet or Chief of Staff is the highest position a Flag Officer can attain in the Federation Starfleet. He is overall in charge of the whole organization. The C-in-C serves as the primary military advisor to the Federation President and the Federation Council, and has operational authority over the whole of Starfleet.
- In January 1 2169, Jonathan Archer was promoted to Chief of Staff in 2168, serving until his retirement.
- In 2293, Fleet Admiral William Smillie the C-in-C.
- Smillie was quickly replaced by Androvar Drake that same year.
- In 2381, Admiral Edward Jellico was appointed Starfleet Commander-in-Chief during that year's Borg invasion.